abstract：:Women with epilepsy have different needs from men, particularly associated with childbearing. Despite clinical guidelines, the care of women with epilepsy remains suboptimal. The aim of this study was to establish whether women with epilepsy recall being given information on topics relating to childbearing. Design of ...

journal_title：Epilepsy research

authors： Bell GS,Nashef L,Kendall S,Solomon J,Poole K,Johnson AL,Moran NF,McCarthy M,McCormick D,Shorvon SD,Sander JW

更新日期：2002-12-01 00:00:00

abstract：:Although treatment of epilepsy easily evolves into a situation of overtreatment, reversing the process can be difficult and time consuming. Benefits of reducing overtreatment may include a decrease in side effects, better seizure control, a simplification in the medication regimen, improved compliance, and reduced cos...

journal_title：Epilepsy research

authors： Bourgeois BF

更新日期：2002-11-01 00:00:00

abstract：:Nonconvulsive status epilepticus (NCSE) is difficult to diagnose but is an important cause of cognitive impairment. Electroencephalogram (EEG) monitoring is required for diagnosis and treatment. Little is known regarding the stability of subclinical epileptiform discharges (SEDs) preceding NCSE nor what strategies may...

journal_title：Epilepsy research

authors： Licht EA,Fujikawa DG

更新日期：2002-09-01 00:00:00

abstract：:The purpose of the study was to evaluate the efficacy and safety of topiramate (TPM) as adjunctive therapy in children, adolescents and young adults with Lennox-Gastaut syndrome (LGS). We performed a prospective open label add-on study in 45 patients (age 4-34 years, mean 15.9 years) with LGS and refractory seizures. ...

journal_title：Epilepsy research

authors： Coppola G,Caliendo G,Veggiotti P,Romeo A,Tortorella G,De Marco P,Pascotto A

更新日期：2002-09-01 00:00:00

abstract：PURPOSE:The stringent dichotomy between focal and generalized epilepsies has become a contentious issue, since neuropathological studies as well as structural and functional imaging data hypothesized the existence of focal brain abnormalities in patients with well-documented idiopathic generalized epilepsy. The aim of ...

journal_title：Epilepsy research

authors： Leutmezer F,Lurger S,Baumgartner C

更新日期：2002-08-01 00:00:00

abstract：:A brief review of kindling is provided, which highlights some important points of historical interest often overlooked by researchers. These points include the fact that the original rating scale of convulsive seizures presented by Racine 'EEG Clin. Neurophysiol 32 (1972) 281'. was based on amygdala kindling, and may ...

journal_title：Epilepsy research

authors： McIntyre DC,Poulter MO,Gilby K

更新日期：2002-06-01 00:00:00

abstract：:Kindling, in the classical sense, involves progressively increasing responsivity to the intermittent repetition of the same 1-s subthreshold electrical stimulation over time, with the amygdala being the area most frequently studied. Such repeated subthreshold stimulation is associated with: lowering of the after-disch...

journal_title：Epilepsy research

authors： Post RM

更新日期：2002-06-01 00:00:00

abstract：PURPOSE:Clobazam (CLB, 1,5-benzodiazepine, 1,5-BZP) has been reported to show unique antiepileptic action profile distinguishing from standard 1,4-BZPs. To further elucidate the action profile of CLB, its effects on the abnormal circling fits (ACFs) and generalized tonic-clonic convulsions (GTCs) in Ihara epileptic rat...

journal_title：Epilepsy research

authors： Miura Y,Amano S,Torii R,Ihara N

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVE:Intensive and quantitative evaluation of the duration, intensity and frequency of tonic and clonic signs of secondarily generalized tonic-clonic seizures (GTCS) in patients with pharmacoresistant partial seizures during topiramate (TPM) treatment. METHODS:Thirty patients suffering from refractory partial sei...

journal_title：Epilepsy research

authors： Wang Y,Zhou D,Wang B,Kirchner A,Hopp P,Kerling F,Pauli E,Stefan H

更新日期：2002-04-01 00:00:00

abstract：RATIONALE AND PURPOSE:Preliminary reports have suggested a possible 'aetiology-specific' efficacy of tiagabine (TGB) in patients with drug-resistant partial epilepsy (DRPE) related to cerebral glial tumors (GTs). This efficacy should be related to selective blocking of GAT-1 transporter by TGB. We presented our open-la...

journal_title：Epilepsy research

authors： Striano S,Striano P,Boccella P,Nocerino C,Bilo L

更新日期：2002-03-01 00:00:00

abstract：:Levetiracetam is a novel antiepileptic drug with an unknown mechanism of action. To-date levetiracetam is not known to be associated with any clinically significant pharmacokinetic interaction. Similarly, levetiracetam has not been associated with any pharmacodynamic interactions. We present four patients with severe ...

journal_title：Epilepsy research

authors： Sisodiya SM,Sander JW,Patsalos PN

更新日期：2002-02-01 00:00:00

abstract：:Felbamate (FBM; 2-phenyl-1,3-propanediol dicarbamate) is an approved antiepileptic drug shown to be effective in a variety of seizure disorders refractory to other treatments. However, its use has been restricted because of association with occurrence of rare cases of aplastic anemia and hepatic failure. Since it was ...

journal_title：Epilepsy research

authors： Husain Z,Pinto C,Sofia RD,Yunis EJ

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:To characterize gabapentin pharmacokinetics in infants and children using a population approach and to identify important demographic and/or physiologic determinants of gabapentin disposition. METHODS:Gabapentin was administered in single doses of 10 mg/kg (N=48 healthy subjects, age 1 month-12 years) or in mu...

journal_title：Epilepsy research

authors： Ouellet D,Bockbrader HN,Wesche DL,Shapiro DY,Garofalo E

更新日期：2001-12-01 00:00:00

abstract：:A strain of Wistar rats, genetic absence epilepsy rats from Strasbourg (GAERS), was selected and inbred over 40 generations for occurrence of spontaneous spike-wave discharges characteristic of absence seizures, simultaneously with a strain of non-epileptic rats (NER). GAERS demonstrate an excessive sensitivity to ant...

journal_title：Epilepsy research

authors： Vergnes M,Boehrer A,He X,Greney H,Dontenwill M,Cook J,Marescaux C

更新日期：2001-11-01 00:00:00

abstract：:Treating a patient with antiepileptic drugs (AEDs) may give rise to unexpected life-threatening adverse events. Despite extensive experimental and clinical testing to ensure safety, most AEDs on the market have been associated with cases of severe cutaneous reactions, serious hematological disorders, or hepatic failur...

journal_title：Epilepsy research

authors： Arroyo S,de la Morena A

更新日期：2001-11-01 00:00:00

abstract：:We have reported long-term clinical follow-up for two siblings with Lafora disease, a brother and sister, one of whom autopsied. Both siblings had repeated attacks of severe myoclonus, tonic and tonic-clonic convulsions, and intractable status epilepticus. The addition of orally administered zonisamide brought about s...

journal_title：Epilepsy research

authors： Yoshimura I,Kaneko S,Yoshimura N,Murakami T

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVE:This study was undertaken to determine whether levetiracetam (Keppra) affected the pharmacokinetic or pharmacodynamic profile of digoxin in healthy adults. METHODS:Seven men and four women (19-48 years old) completed this double-blind, placebo-controlled study. Each received digoxin 0.25 mg once daily (0.5 m...

journal_title：Epilepsy research

authors： Levy RH,Ragueneau-Majlessi I,Baltes E

更新日期：2001-08-01 00:00:00

abstract：:Physical maturation is one of the essential developmental processes during childhood and adolescence, which can be adversely affected by a number of internal and external factors. An important side effect associated with the long-term use of some antiepileptic drugs is change in body weight, followed by an increased r...

journal_title：Epilepsy research

authors： Ueberall MA

更新日期：2001-07-01 00:00:00

abstract：:There is increasing clinical and experimental evidence that hormones, in particular sex steroid hormones, influence neuronal excitability and other brain functions. The term 'neuroactive steroids' has been coined for steroids that interact with neurotransmitter receptors. One of the best characterized actions of neuro...

journal_title：Epilepsy research

authors： Beyenburg S,Stoffel-Wagner B,Bauer J,Watzka M,Blümcke I,Bidlingmaier F,Elger CE

更新日期：2001-05-01 00:00:00

abstract：:This study was planned so as to evaluate whether magnetic field exposure has any significant effect on the pentylenetetrazol (PTZ)-induced seizures. Mice were exposed to 50 Hz, 2 G (0.2 mT) magnetic field in glass cages for 1 h. Sham exposure was produced by turning off the current while the animals were in the same e...

journal_title：Epilepsy research

authors： Keskil IS,Keskil ZA,Canseven AG,Seyhan N

更新日期：2001-04-01 00:00:00

abstract：:The present study intends to identify factors that predict postoperative clinical outcome in patients with gangliogliomas (GG) and dysembryoplastic neuroepithelial tumors (DNT). We evaluated the medical records of 45 patients with GG and 13 patients with DNT, treated surgically between 1985 and 1995. We assessed sever...

journal_title：Epilepsy research

authors： Aronica E,Leenstra S,van Veelen CW,van Rijen PC,Hulsebos TJ,Tersmette AC,Yankaya B,Troost D

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVE:This was the first proof of principle clinical trial assessing the efficacy and safety of rufinamide as adjunctive therapy in epileptic patients. The pharmacokinetic (PK) profile of rufinamide was also determined. METHODS:Fifty patients with diagnoses of partial or primary generalized tonic-clonic seizures w...

journal_title：Epilepsy research

authors： Pålhagen S,Canger R,Henriksen O,van Parys JA,Rivière ME,Karolchyk MA

更新日期：2001-02-01 00:00:00

abstract：:Four patients with complex partial seizure disorder whose positron emission tomography (PET) scans show sustained hyperperfusion of the epileptiform focus 12-24 h after a seizure episode are presented. Three of these patients underwent same day Fluorine-18 (18F) deoxyglucose (FDG) PET scans, which showed hypometabolis...

journal_title：Epilepsy research

authors： Tatlidil R

更新日期：2000-12-01 00:00:00

abstract：:Developmental changes of transport of drugs into the brain play an important role in ontogenetic neuropharmacology. Two convulsant drugs with different mechanisms of action (glutamate and bicuculline methiodide) were chosen to demonstrate these changes in developing rats. High dose of glutamate (4 g/kg i.p.) induced b...

journal_title：Epilepsy research

authors： Mares P,Chino M,Kubová H,Mathern P,Veliký M

更新日期：2000-12-01 00:00:00

abstract：:Epilepsy is a common neurological disease and encompasses a variety of disorders with paroxysms. Although there is a genetic component in the pathogenesis of epilepsy, the molecular mechanisms of this syndrome remains poorly understood. Linkage analysis and positional cloning have not been sufficient tools for determi...

journal_title：Epilepsy research

authors： Hirose S,Okada M,Kaneko S,Mitsudome A

更新日期：2000-10-01 00:00:00

abstract：:Several interacting genetic factors are likely to be involved in the epileptogenesis of idiopathic generalized epilepsies (IGE). Neurotransmitter transporters play a central role in the fine tuning of neurotransmission by removal of released neurotransmitters from the synaptic cleft. The present association study test...

journal_title：Epilepsy research

authors： Sander T,Berlin W,Ostapowicz A,Samochowiec J,Gscheidel N,Hoehe MR

更新日期：2000-08-01 00:00:00

abstract：:The Mongolian gerbil is known as an animal model that often exhibits spontaneous seizures that are characteristic of human epilepsy. Whereas there is much more information available relating this phenomenon to anatomical and electrophysiological characteristics of the hippocampal formation, the somatosensory cortex ha...

journal_title：Epilepsy research

authors： Kato M,Ito M,Seto-Ohshima A

更新日期：2000-07-01 00:00:00

abstract：:Single photon emission computed tomography (SPECT) has frequently been used to investigate cerebral brain perfusion (CBP) occurring ictally and inter-ictally in epileptic patients. Several studies have addressed the multimodal analysis of the modifications occurring in cerebral areas involved in seizure activity, by c...

journal_title：Epilepsy research

authors： Marrosu F,Puligheddu M,Giagheddu M,Cossu G,Piga M

更新日期：2000-06-01 00:00:00

abstract：PURPOSE:The intracarotid amytal test is commonly used as a predictor of memory dysfunctioning after anterior temporal lobe resection (ATL) for intractable epilepsy. Asymmetry in memory scores can provide focus lateralizing information. In this study the predictive value of a set of Wada test parameters was analyzed, in...

journal_title：Epilepsy research

authors： Alpherts WC,Vermeulen J,van Veelen CW

更新日期：2000-05-01 00:00:00

abstract：:Depression is a frequent psychiatric symptom in epilepsy and has been related to epilepsy of temporal origin, especially of left-sided foci. No study differentiated the precise localization of the epileptogenic lesion within the temporal lobe. Regarding this issue, we evaluated depression assessed by the Beck Depressi...

journal_title：Epilepsy research

authors： Quiske A,Helmstaedter C,Lux S,Elger CE

更新日期：2000-04-01 00:00:00

abstract：:The genes of two group III metabotropic glutamate receptors, mGluR7 and 8, are candidate susceptibility genes for epilepsy. The Tyr433Phe polymorphism of mGluR7 and a novel polymorphism in the mGluR8 gene located 29 bp after the termination codon (2756C/T) were investigated in case control association studies performe...

journal_title：Epilepsy research

authors： Goodwin H,Curran N,Chioza B,Blower J,Nashef L,Asherson P,Makoff AJ

更新日期：2000-03-01 00:00:00

abstract：:To further elucidate the inheritance pattern and range of phenotypic manifestations of benign familial temporal lobe epilepsy (FTLE), we report a large family recently identified in southern Italy. There were 8 patients (4 men), ranging in age from 31 to 68 years in three generations. One affected patient was deceased...

journal_title：Epilepsy research

authors： Gambardella A,Messina D,Le Piane E,Oliveri RL,Annesi G,Zappia M,Andermann E,Quattrone A,Aguglia U

更新日期：2000-02-01 00:00:00

abstract：:The postictal behavioral depression (PBD), characterized by behavioral immobility and unresponsiveness to environmental stimuli, observed after a stage 5 kindling seizure is opioid dependent. Morphine injection prolongs while naloxone and naltrexone (opioid antagonists) reduce or eliminate PBD. Opioids have clear rewa...

journal_title：Epilepsy research

authors： Paredes RG,Muzzi G,Aguirre E,Romero V

更新日期：2000-02-01 00:00:00

abstract：:Aminergic signalling in the CNS is terminated by clearance of neurotransmitters from the synapse via high affinity transporter molecules in the presynaptic membrane. Relatively recent sequence identification of these molecules has now permitted the initiation of studies of regulation of transporter function at the cel...

journal_title：Epilepsy research

authors： Figlewicz DP

更新日期：1999-12-01 00:00:00

abstract：:The development of epilepsy and a progressive increase in susceptibility to seizures may involve changes in inhibitory and excitatory systems from the beginning of the process. The present study was focused to analyze the opioid peptide changes induced by a chemical sub-convulsant stimulation. Experiments were carried...

journal_title：Epilepsy research

authors： Rocha L,Cano A,Cruz C,Omaña-Zapata I,Villalobos R,Maidment NT

更新日期：1999-11-01 00:00:00

abstract：:The characteristics of evoked potentials in patients with dentatorubral-pallidoluysian atrophy (DRPLA) were investigated. Twelve patients with DRPLA and three patients with progressive myoclonic epilepsy (PME) attributable to other causes participated in the study. In 11 out of the 12 patients, the diagnosis of DRPLA ...

journal_title：Epilepsy research

authors： Kasai K,Onuma T,Kato M,Kato T,Takeya J,Sekimoto M,Watanabe K,Minami N,Goto Y,Minabe Y

更新日期：1999-10-01 00:00:00

abstract：:The GABAergic system has long been implicated in epilepsy with defects in GABA neurotransmission being linked to epilepsy in both experimental animal models and human syndromes (Olsen and Avoli, 1997). However, to date no human epileptic syndrome has been directly attributed to an altered GABAergic system. The observe...

journal_title：Epilepsy research

authors： DeLorey TM,Olsen RW

更新日期：1999-09-01 00:00:00

abstract：:The aim of the present study was to evaluate the risk of intrauterine growth delay in the offspring of epileptic mothers and to quantify the risks of intrauterine exposure to antiepileptic drugs (AEDs). Data concerning 870 newborns, prospectively collected in Canada, Japan and Italy, using the same study design, were ...

journal_title：Epilepsy research

authors： Battino D,Kaneko S,Andermann E,Avanzini G,Canevini MP,Canger R,Croci D,Fumarola C,Guidolin L,Mamoli D,Molteni F,Pardi G,Vignoli A,Fukushima Y,Kan R,Takeda A,Nakane Y,Ogawa Y,Dansky L,Oguni M,Lopez-Ciendas I,Sher

更新日期：1999-08-01 00:00:00

abstract：:CYP2C9 is mainly responsible for the metabolic clearance of phenytoin and (S)-warfarin. We have shown previously that mutations in the CYP2C9 gene are associated with diminished metabolism of (S)-warfarin, and so we have now studied the metabolism of phenytoin to its primary inactive metabolite, (S)-pHPPH, by these mu...

journal_title：Epilepsy research

authors： Rettie AE,Haining RL,Bajpai M,Levy RH

更新日期：1999-07-01 00:00:00

abstract：:Opioid peptide release was monitored in the amygdala and hippocampus of freely moving rats following a single oral administration of gabapentin using microdialysis. Extracellular opioid peptide levels were elevated above basal levels in the amygdala within the first 60 (54%) and 90 min (68%) after gabapentin administr...

journal_title：Epilepsy research

authors： Rocha L,Ondarza-Rovira R,Maidment NT

更新日期：1999-05-01 00:00:00